Composition

Ingredients: Neomycin Sulfate 
Appearance: White or light yellow powder

Pharmacological action

Pharmacodynamics 
Neomycin belong to the aminoglycoside antibiotics,the antibacterial spectrum is similar with kanamycin.It has a strong antibacterial action on most of the gram-negative bacterium,such as escherichia coli, proteusbacillus vulgaris, salmonella and pasteurella multocida,also sensitive to staphylococcus aureus. Pseudomonas aeruginosa, gram-positive bacterium(except the staphylococcus aureus), rickettsia, anaerobion and fungus resistance to this product. 
Pharmacokinetics 
Neomycin taken orally and local application absorb less,after taken orally 3% of the amount excreted in urine,most unchanged excreted in faeces.The intestinal mucosa inflammation or anabrosis can make the absorption increase.Injection absorption quickly,the process in vivo is similar with kanamycin.

Drug interactions

1. Combination use with macrolide antibiotics can treat the mammitis caused by gram-positive bacterium. 
2.For oral administration can affect the absorption of digitalis drug,vitamin A or vitamin B_12. 
3.Combination use with penicillin or cephalosporins can produce synergistic effect. 
4.The antibacterial action of this product become strong when in alkaline environment, combination use with alkaline drug can increase the antibacterial effect,but the toxicity of chlorobenzene increased. 
5.The positive ion such as Ca²⁺，Mg²⁺，Na⁺，NH₄⁺，and K⁺ can inhibit the antimicrobial activity 
6.Used with cephalosporin, dextranum, diuretics(such as furosemide), erythrocin,can enhance the ototoxicity of this product. 
7. Muscle relaxant(such as succinylcholine chloride) or the medicines have this effect can enhance the neuromuscular blockade effect of this product.

Indications

Used to treat the colibacillosis, pullorum disease which caused by gram-negative bacterium such as escherichia coli and salmonella of poultry.

Usage and Dosage

Calculated on this product 
Mix drink:Each 1L water,poultry 0.154-0.231g. combination use 3-5 days.

Adverse drug reaction

The neomycin is the most hazardous in aminoglycosides,but the taken orally and local application the toxic effect is less.

Precautions

(1)Egg laying period is forbidden 
(2)For oral administration may affect the absorption of vitamin A and vitamin B_12.

Withdrawal Period

Chicken 5 days, turkey 14 days.

Specification

100g：32.5g（32.5 million units） 
Packing 
100g/bag

Storage

Dry, sealing  preservation

Valid Date

2 years